Nicotine에 의한 자발성고혈압백서(自發性高血壓白鼠)의 혈장 Cholesterol 농도의 변동

• 영문명: Effect of Nicotine on Plasma Cholesterol Level in Spontaneously Hypertensive Rats
• 발행기관: 대한생리학회
• 저자명: 류호충(Yoo, Ho-Choong) 고상돈(Koh, Sang-Don) 신홍기(Shin, Hong-Kee) 김기순(Kim, Kee-Soon)
• 간행물 정보: 『대한생리학회지』제16권 제2호, 137~146쪽, 전체 10쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1982.12.31

영문 초록

The present study was undertaken to find out fasting total plasma cholesterol levels of SHR at different phases(labile, established and malignant) in the course of hypertension development and also to investigate effect of nicotine on plasma cholesterol levels of these animals. In nicotine administered group, 2.18 mg/kg nicotine was given daily for six weeks. The results obtained are as follows; 1) Mean total plasma cholesterol levels of SHR at labile, established and malignant phases were 104.6±3.1 mg/dlThe present study was undertaken to find out fasting total plasma cholesterol levels of SHR at different phases(labile, established and malignant) in the course of hypertension development and also to investigate effect of nicotine on plasma cholesterol levels of these animals. In nicotine administered group, 2.18 mg/kg nicotine was given daily for six weeks. The results obtained are as follows; 1) Mean total plasma cholesterol levels of SHR at labile, established and malignant phases were 104.6±3.1 mg/dl, 120.8±2.6 mg/dl and 136.6±2.5 mg/dl respectively. The total plasma cholesterol level generally increased with age of experimental animals. 2) After administration of nicotine (2.18 mg/kg/day) for six weeks, mean total plasma cholesterol levels of SHR at labile, established and malignant phases were 130.2±3.1 mg/dl, 150.4±3.3 mg/dl and 166.6±3.2 mg/dl, respectively. The result of present study strongly suggests that nicotine has a positive relationship with plasma cholesterol levels in SHR. , 120.8±2.6 mg/dl and 136.6±2.5 mg/dl respectively. The total plasma cholesterol level generally increased with age of experimental animals. 2) After administration of nicotine (2.18 mg/kg/day) for six weeks, mean total plasma cholesterol levels of SHR at labile, established and malignant phases were 130.2±3.1 mg/dl, 150.4±3.3 mg/dl and 166.6±3.2 mg/dl, respectively. The result of present study strongly suggests that nicotine has a positive relationship with plasma cholesterol levels in SHR.