Clozapine에 의한 무과립구증

• 영문명: Clozapine-induced Agranulocytosis
• 발행기관: 대한신경정신의학회
• 저자명: 이홍식 김지현 이희상 도정호 김찬형 유계준
• 간행물 정보: 『신경정신의학』제36권 제1호, 204~208쪽, 전체 5쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1997.01.30

영문 초록

The authors reported one case of agranulocytosis that occurred in the clozapine treatment in a 34- year-old male patient with chronic schizophrenia. Agranulocytosis, a WBC count of 2700 with 4% neutrophils, developed on Day 25 of clozapine treatment, when clozapine was stopped. On Day 26, he became febrile with temperature of 38℃ and he was treated with antibiotics, Claforan for 4 days, and received carefully daily blood monitering and observation. Six days after stopping the administration of clozapine, his WBC exhibited the normal range with increasing numbers of neutrophils(WBC, 6000/mm3；neutrophils, 43%) and he began to improve clinically. Also, we described the recent review of incidence, the natural history and implicated possible mechanisms for clozapine-induced agranulocytosis.

목차

서 론

증 례

고 찰

결 론

참 고 문 헌

키워드

Schizophrenia Clozapine Agranulocytosis