정신분열증 환자에서 Haloperidol이 혈청 Interleukins 농도에 미치는 영향

• 영문명: The Effect of Haloperidol on Serum Levels of Interleukins in Schizophrenic Patients
• 발행기관: 대한신경정신의학회
• 저자명: 김용구 이민수 서광윤
• 간행물 정보: 『신경정신의학』제36권 제1호, 80~84쪽, 전체 5쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1997.01.30

영문 초록

Objective：Altered interleukin(IL) regulation has been regarded as an additional proof that schizophrenia has a viral-autoimmunological background. However, it is possible that abnormalities of ILs may represent a neuroleptic artifact rather than a finding intrinsic to the disorder. Therefore, we studied the effect of haloperidol on serum IL level in schizophrenic patients. Methods：We measured serum levels of IL-1β, IL-2, and IL-6 using quantitative sandwich ELISA method at the day 0(before-medication), week 4 and week 8 in 20 male schizophrenic patients. Results：There were no significant differences in serum IL-1β, IL-2, and IL-6 levels between before medication and at either week 4 and week 8 after haloperidol administration. Conclusions：These findings suggest that at least 8 weeks of haloperidol administration does not affect serum IL-1β, IL-2 and IL-6 levels in male schizophrenics

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키워드

Haloperidol Interleukins Immune function Schizophrenia