Hippocampal Neurochemical Pathology in Patients with Panic Disorder

• 발행기관: 대한신경정신의학회
• 저자명: Murad Atmaca Hanefi Yildirim M. Gurkan Gurok Muammer Akyol Filiz Koseoglu
• 간행물 정보: 『Psychiatry Investigation』제9권 제2호, 161~165쪽, 전체 5쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2012.06.30

영문 초록

Objective-In the present study, we measured hippocampal N-acetyl-l-aspartate (NAA), choline (CHO) and creatine (CRE) values in patients with panic disorder and healthy control subjects using in vivo 1H MRS. Methods-We scanned 20 patients meeting Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) criteria for panic disorder and 20 matched healthy controls with a 1.5 Tesla GE Signa Imaging System and measured of NAA, CHO, and CRE in hippocampal regions. Results-When NAA, CHO and CRE values were compared between groups, statistically significant lower levels for all ones were detected for both sides. Conclusion-Consequently, in the present study we found that NAA, CHO and CRE values of the patients with panic disorder were lower than those healthy controls. Future studies involving a large number of panic patients may shed further light on the generalizability of the current findings to persons with panic disorder.

목차

INTRODUCTION

METHODS

RESULTS

DISCUSSION

REFERENCES

키워드

N-acetylaspartate Creatine Choline Panic disorder 1H MRS