Do Child Abuse and Maltreatment Increase Risk of Schizophrenia?

• 발행기관: 대한신경정신의학회
• 저자명: Lucia Sideli Alice Mule Daniele La Barbera Robin M. Murray
• 간행물 정보: 『Psychiatry Investigation』제9권 제2호, 87~99쪽, 전체 13쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2012.06.30

영문 초록

Introduction-Although childhood abuse is a recognised risk factor for depression, post-traumatic stress disorder, and substance misuse, its role in the aetiology of psychotic disorder remained controversial. This is in part because the putative effect of childhood trauma on psychosis has been mostly evaluated by small, cross sectional, uncontrolled studies that raised methodological issues. Methods-Papers concerning the association between childhood trauma and psychotic disorders (to November, 2011) were identified using a comprehensive search of PubMed, Psychinfo, and Scopus and analysing reference list of relevant papers. A narrative synthesis was used to summarise results. Results-An association between childhood abuse and psychotic symptoms was consistently reported by large cross sectional surveys with an effect ranging from 1.7 to 15. However, we cannot conclude that the relationship is causal as lack of longitudinal studies prevent us from fully excluding alternative explanations such as reverse causality. Gender, cannabis use, and depressive and post-traumatic stress disorder symptoms appear to moderate the effect of childhood trauma on psychotic disorders. However, specificity of childhood abuse in psychotic disorders and, particularly, in schizophrenia has not been demonstrated. Conclusion-Although the association between childhood abuse and psychosis has been replicated, the etiological role of such early adversity has yet to be fully clarified. So far none of the studies reported support the hypothesis that childhood abuse is either sufficient or necessary to develop a psychotic disorder. It seems likely that any effect of childhood abuse on schizophrenia needs to be understood in terms of genetic susceptibility and interaction with other environmental risk factors.

목차

INTRODUCTION

PREVALENCE OF CHILDHOOD ABUSE IN THE GENERAL POPULATION AND ITS ASSOCIATION WITH PSYCHIATRIC DISORDERS

RECENT REVIEWS ON CHILDHOOD ABUSE AND PSYCHOSIS

CROSS SECTIONAL SURVEYS

COHORT STUDIES

STUDIES ON HIGH RISK POPULATIONS

SPECIFICITY OF CHILDHOOD TRAUMA TO SCHIZOPHRENIA: COMPARISON WITH OTHER CLINICAL POPULATIONS

THE ROLE OF SPECIFIC TYPE OF ADVERSITIES IN THE AETIOLOGY OF SCHIZOPHRENIA

PUTATIVE MEDIATING AND MODERATING FACTORS: GENDER, AFFECTIVE AND POST-TRAUMATIC SYMPTOMS, AND SUBSTANCE MISUSE

MECHANISM OF RISK

CONCLUSION

REFERENCES

키워드

Schizophrenia Child abuse Maltreatment Etiology Review