정신분열병 및 양극성 장애에서 종양괴사인자 - 알파 유전자 다형성의 연합 연구

• 영문명: Association Study of Tumor Necrosis Factor-Alpha Gene Polymorphism in Schizophrenia and Bipolar Disorder
• 발행기관: 대한신경정신의학회
• 저자명: 김종우 전태연 배치운 이경욱
• 간행물 정보: 『신경정신의학』제42권 제5호, 559~564쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2003.09.30

영문 초록

Objectives：The role of cytokines has been one of the focal points of etiologic research in major psychiatric disorders. This study was designed to analyze the polymorphism of TNF-α and to investigate its relationship with schizophrenia and bipolar disorder. Methods：241 schizophrenic patients and 89 bipolar patients diagnosed by DSM-IV criteria were included as patient groups and 125 normal poplulation from the Catholic Hemopoietic Stem Cell Information Bank (Seoul, Korea) were used as a control group. DNA was extracted from the whole blood, amplified by polymerase chain reaction, and digested by NcoI. Then the obtained RFLP of two alleles, TNFA*1 with 87 bp and 20 bp, and TNFA*2 with 107 bp were assessed. All data were analyzed by χ2 test. Results：The genotype and allele distributions in patients with bipolar disorder were significantly different from those in the controls. There were no significant differences in genotype frequencies of TNFA*1/1, TNFA*1/2, and allelic frequencies of TNFA*1 and TNFA*2 between the schizophrenic patients and the controls. Conclusion：In the present study we observed a significant association between the TNFA*2 allele with bipolar disorder, with negative result on the association of the polymorphism of TNF-α gene with schizophrenia. Consecutive further studies including diverse clinical variables would be required.

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키워드

Schizophrenia Bipolar disorder TNF-α gene polymorphism