정신분열병의 선택적 주의력 저하의 보상 기전

• 영문명: Compensatory Neural Correlates of Selective Attention Deficit in Schizophrenics Showing Normal Accuracy during Stroop
• 발행기관: 대한신경정신의학회
• 저자명: 최지욱 정범석 김지웅 김성윤 권준수 전덕인 김창윤
• 간행물 정보: 『신경정신의학』제43권 제6호, 674~680쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2004.11.30

영문 초록

Objectives：This study investigated the compensatory neural correlate of selective attention deficit in schizophrenics showing near-normal performance. Methods：A ‘modified Stroop’ was developed that can be used measure the response time during functional imaging. An event-related functional magnetic resonance imaging study was carried out in 10 clinically stabilized schizophrenics and 10 healthy controls during the performance of a ‘modified Stroop’. In the ‘modified Stroop’, the subjects were required to respond with a two-button mouse to whether or not the color of a subsequent word corresponded to one of T-shirt. The significantly activated brain regions were investigated in a voxel-wise t-test of the Stroop load. Results：Schizophrenics, compared with healthy controls, showed poorer response time, but had similar accuracy. Compensatory activation in the right inferior frontal gyrus (IFG) was observed in schizophrenics. The left paracingulate sulcus was less activated in the schizophrenics than in the healthy controls. Conclusion：These results suggest that, in schizophrenics showing a normal accuracy during the Stroop, selective attention deficits might be related to the left paracingulate sulcus as well as the anterior cingulate. In addition, their deficits may be compensated with the right IFG

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키워드

Schizophrenia Magnetic resonance imaging Selective attention Paracingulate sulcus Inferior frontal gyrus