급성 조증에서 기분안정제와 리스페리돈의 병합 투여 효과： 다기관 개방연구

• 영문명: Risperidone in Combination with Mood Stabilizers for Acute Mania： A Multicentre, Open Study
• 발행기관: 대한신경정신의학회
• 저자명: 김광수 배치운 윤진상 김영훈 이양현 지익성 이철 송혜경 최성구 박원명
• 간행물 정보: 『신경정신의학』제44권 제2호, 207~212쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2005.03.30

영문 초록

Objective：The primary purpose of this study was a replication of the effectiveness and tolerability of risperidone in the treatment of patients with acute mania in very larger cohort in naturalistic treatment setting to extend the data on the effect and tolerability of risperidone in the treatment of patients with acute mania to Asian population. Methods：A total of 909 patients with DSM-IV criteria of bipolar disorder current manic and hypomanic episode, entered this large, open, multicentre study. The Young Mania Rating Scale (YMRS), Clinical Global Impression (CGI) and Simpson- Angus Rating Scale (SARS) were measured at baseline and weeks 1, 3 and 6, for the assessment of effectiveness and extrapyramidal symptom (EPS). Results：This study showed statistically significant reduction of scores on the YMRS and CGI-s (mean change=-23.5± 11.8, p<0.0001；mean change=-2.7±1.5, p<0.0001, respectively) from the baseline to the endpoint (week 6). Number of patients with 50% reduction or more in the YMRS and CGI-s scores was 693 (77.8%) and 630 (70.7%) at endpoint, respectively. There were no statistically significant increments of scores on SARS. Risperidone was generally well tolerated. Conclusion：The present larger open study demonstrates that risperidone add-on therapy is effective and tolerable in treatment of bipolar disorder, replicating results in various controlled and uncontrolled studies from Western countries.

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키워드

Risperidone Bipoar disorder Effectiveness Tolerability