한국인에서 5-HT1Dβ 유전자다형성과 성격 특성

• 영문명: Polymorphisms in 5-HT1Dβ Receptor Gene and Personality Traits in a Korean Population
• 발행기관: 대한신경정신의학회
• 저자명: 김세주 김찬형 최낙경 홍현주 김성준 조대연 이홍식
• 간행물 정보: 『신경정신의학』제44권 제2호, 185~190쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2005.03.30

영문 초록

Objectives：Recently, there has been a growing enthusiasm in biological approach to personality; the identification of genes responsible for particular personality traits. The aim of this study was to investigate the association between the 5-HT1Dβ G861C polymorphism and personality traits. Methods：We recruited 218 normal subjects. The Korean version of the Temperament and Character Inventory (TCI) was used to assess personality traits. From blood samples taken from the subjects, DNA was isolated using standard techniques and the HT1Dβ G861C polymorphism was genotyped by means of polymerase chain reaction and Homogeneous MassEXTEND method. We classified the subject into the GG, CG, and GG groups according to their genotypes. The differences in the temperament factors of the TCI between homozygote group (GG+CC genotype) and heterozygote group (CG genotype) were tested. Results：The heterozygote group had significantly lower Harm avoidance (HA) scores and higher Self-directedness scores (SD) than the homozygote group. Conclusion：In conclusion, we found some associations between the 5-HT1Dβ G861C polymorphism and the personality dimension HA and SD in a normal population.

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키워드

Temperament and character inventory 5-HT1Dβ receptor Polymorphism Harm avoidance Self-directedness