GABAAα6 유전자 다형성에 따른 알코올 금단 증상의 발현 차이

• 영문명: The Differential Manifestation of Alcohol Withdrawal Symptoms Related to GABAA α6 Polymorphism
• 발행기관: 대한신경정신의학회
• 저자명: 한덕현 최정은 이병용 김영훈 김혜원 이혜경
• 간행물 정보: 『신경정신의학』제44권 제2호, 191~197쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2005.03.30

영문 초록

Introduction：The gamma-aminobutyric acid type A (GABAA) receptor is an important pharmacological target of alcohol. The phamacological characteristics of the receptor are largely determined by its subunit composition. Compared with all other α subtypes, the α6- containing receptors are more sensitive to GABA and less sensitive to benzodiazepines. The purpose of this study was to address a role for GABAAα6 receptor subunit gene in the development of alcohol dependence. The differential manifestation of alcohol withdrawal symptoms related to GABAAα6 polymorphism in patients treating with benzodiazepines was also examined. Methods：Eighty-seven inpatients with alcohol dependence, and sixty healthy controls were evaluated using CIWA-Ar scale. Each patient was genotyped for GABAAα6 subunit. Association between GABAAα6 polymorphism and severity of withdrawal symptom were determined. Results：No significant difference was found in GABAAα6 receptor genetic type and allelic distribution between the alcohol dependent and control subject. Tremor was more severe in CC than TT type. TT type had higher degree of anxiety, agitation and headache than CC type. The GABAAα6 C allele increased the average score of tremor significantly, and T allele increased that of agitation. Conclusion：The results suggested that GABAAα6 genetic polymorphism was not associated with alcohol dependence and with severity of alcohol withdrawal symptoms. But in benzodiazepine treated patients, GABAAα6 polymorphism and allelic type show the difference in severity of each withdrawal symptom. These differences of severity are partly responsible for the unique pharmacological properties associated with the GABAAα6 subunit.

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키워드

GABA receptor Benzodiazepine Alcohol withdrawal Alcohol dependence Genetic polymorphism