자폐 스펙트럼 장애 아동의 언어 능력에 미치는 도네페질의 효과

• 영문명: The Effect of Donepezil on Language Functions in Children with Autism Spectrum Disorders
• 발행기관: 대한신경정신의학회
• 저자명: 장원석 홍성도 신석호
• 간행물 정보: 『신경정신의학』제45권 제1호, 64~68쪽, 전체 5쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2006.01.30

영문 초록

Objectives：Recent studies in autistic brain samples have shown diminished acetylcholine and nicotinic receptor activity. We hypothesized that acetylcholinergic enhancement may pharmacologically improve some autistic characteristics. Donepezil hydrochloride, a cholinesterase inhibitor, was studied in few studies which showed improvement in the expressive and receptive speech of autistic children. We therefore undertook an open label trial to evaluate this effect on speech function in Korean autistic children. Methods：Twenty-one patients (18 males, 3 females, average age 77.9±23.7 months), with a diagnosis of autism spectrum disorder enrolled in a 12-week open label trial of donepezil hydrochloride. Changes were evaluated by PLS (Preschool language scale). Testing was administered at baseline and at 12-week follow-up. Results：Test administered at baseline and at 12-week follow-up showed gains in both expressive and receptive speech functions. Conclusion：Donepezil hydrochloride, a cholinesterase inhibitor, appears to improve expressive and receptive speech functions of autistic children

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키워드

Autism Autism spectrum disorder Donepezil hydrochloride