노인인구에서 ApoE 유전자형에 따른 머리둘레와 인지기능간의 연관성

• 영문명: Correlation between Head Circumference and Cognition in the Elderly by ApoE Genotype
• 발행기관: 대한신경정신의학회
• 저자명: 김경란 오병훈 이준영 김은아 정해관 이동우 홍창형
• 간행물 정보: 『신경정신의학』제46권 제3호, 254~261쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2007.05.30

영문 초록

Objectives：The aim of this study is to find out the effect of ApoE genotype on correlation between head circumference and cognition of the elderly in the community. Methods：A total of 1,152 subjects (380 men and 772 women) aged 60-91 years were analyzed from preliminary data of GDEMCIS (Gwangju Dementia and MCI Study). The study questionnaire consisted of demographic characteristics, current and past illness history, drug history and K-MMSE (Korean version-Mini Mental State Examination). We also measured the head circumference and examined ApoE genotype. Results：On regression analysis, as head circumference becomes smaller, K-MMSE scores decreased adjusted by age, sex, educational level, ApoE ε4 allele, current smoking and alcohol drinking status (β=0.15, p=0.04). Only in the lowest quartile group, presence of ApoE ε4 allele reduced K-MMSE scores adjusted by age, sex, educational level, height, current alcohol drinking and smoking status (β=-1.39, p=0.008). Conclusion：These results suggest that head circumference may have an influence on K-MMSE scores, and presence of ApoE ε4 allele may be a medicating factor

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키워드

Head circumference Cognition K-MMSE Elderly ApoE genotype Brain reserve