자살행동의 소인과 생물학적 인자의 관련

• 영문명: Association of Diathesis and Biological Factors in Suicidal Behavior
• 발행기관: 대한신경정신의학회
• 저자명: 이분희 김용구
• 간행물 정보: 『신경정신의학』제46권 제3호, 195~200쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2007.05.30

영문 초록

Suicide is a significant public health issue and a major cause of death throughout the world. There are significant evidences that the activity of 3 neurobiological systems has a role in the pathophysiology of suicidal behavior：a deficiency of serotonergic system, a hyperactivity of the hypothalamic-pituitary-adrenal axis, and an excessive release of noradrenaline. These neurobiological abnormalities might correlate with the diathesis of suicide including pessimism and aggression. Dysfunction of the serotonergic system is thought to be associated with disturbances in the regulation of impulsivity and aggression, which may be traitdependent factor. Hyperactivity of the hypothalamo-pituitary-adrenal axis and excessive activity of the noradrenergic system appear to be involved in the response to stressful events, which may be state-dependent factor. In the future, more understanding several aspect of suicidal behavior and the neurobiology of suicide can help detect promising predictors of suicidal behavior and treatment interventions.

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키워드

Aggression Hypothalamic-pituitary-adrenal axis Impulsivity Noradrenaline Serotonin Suicide Stress