주의력결핍 과잉행동장애 아동에서 틱 장애 동반 여부에 따른 확산 텐서 영상 비교 연구

• 영문명: Comparison of Diffusion Tensor Imaging in Attention Deficit Hyperactivity Disorder Boys with or without Comorbid Tic Disorders
• 발행기관: 대한신경정신의학회
• 저자명: 최지욱 임명호 이창화 박진균 손정우 심세훈 유인규 강현수 정범석
• 간행물 정보: 『신경정신의학』제47권 제5호, 493~502쪽, 전체 10쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2008.09.30

영문 초록

Objectives：Diffuse tensor imaging (DTI) was applied to explore the difference in regional distribution and extent of white matter (WM) abnormalities in boys with Attention-deficit/hyperactivity disorder (ADHD) versus boys with comorbid ADHD and tic disorders. Methods：Fifteen boys with ADHD (mean age 9.3±1.8), 24 ADHD boys with chronic tic disorder or Tourette’s disorder (9.9±1.2) and 9 age-, gender-matched controls (9.2±1.8) received DTI assessments. Fractional Anisotropy (FA) maps of WM were compared between groups with a voxel-wise analysis after intersubject registration to MNI space. Results：Both groups, ADHD group and ADHD with tic disorder group, commonly showed decreased FA than healthy control group in left cerebellar middle peduncle and right frontal lobe, increased FA in right middle occipital WM. In the common areas of left cerebellar middle peduncle and right middle occipital WM, comorbid group showed broader areas of significant FA. The comorbid group also showed increased FA in right cerebellar peduncle, additionally. Conclusion：The findings in ADHD group support previous ADHD hypothesis of the functional abnormalities in corticocerebellar circuit, and suggest that ADHD might have more complicated pathology of neuronal circuit including occipital visual system. The comorbid group showed common areas of overlapping but more extensive abnormalities and also had additional WM abnormalities. ADHD with chronic tic disorders may represent a severe form of ADHD with additional regions of abnormal connectivity.

목차

서 론

방 법

결 과

고 찰

결 론

REFERENCES

키워드

ADHD Tic disorders Diffusion tensor imaging