북한이탈주민의 외상 후 스트레스 장애와 자연살해세포 활성

• 영문명: Natural Killer Cell Activity in North Korean Defectors with PTSD
• 발행기관: 대한신경정신의학회
• 저자명: 김병창 정성훈 임효덕 최종혁 전정희 전양환
• 간행물 정보: 『신경정신의학』제47권 제5호, 481~487쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2008.09.30

영문 초록

Objectives：The objective of this study was to evaluate an association between posttraumatic stress disorder (PTSD) and altered immunity in North Korean defectors who were more likely to develop medical conditions and other stress-related psychiatric disorders. Methods：Twenty-four North Korean defectors with PTSD and twenty-two controls without PTSD were recruited from the resettlement and training center for North Korean defectors in South Korea. Peripheral T lymphocyte subsets, natural killer (NK) cells, NK cell activity and plasma hormones (ACTH and cortisol) were obtained from all subjects. We also applied the Hamilton Rating Scale for Depression (HAM-D) and Hamilton Rating Scale for Anxiety (HAM-A) for all subjects. Results：We found NK cell activity was relatively lower than number of NK cells in North Korean defectors with PTSD. Subjects with PTSD had higher HAM-D and HAM-A scores than controls. However, there were no statistical differences in ACTH, cortisol, CD3, CD4, CD8, CD4/CD8 ratio, CD19 and CD56 between the two groups. Conclusion：These findings suggest North Korean defectors with PTSD show higher levels of depression, anxiety and impaired or weak immune function in NK cells

목차

서 론

방 법

결 과

고 찰

REFERENCES

키워드

NK cells Posttraumatic stress disorder North Korean defectors Immunity