정신분열병의 비이환 형제 자매 집단에서 얼굴 정보처리 관련 뇌회로의 이상： 기능적 뇌자기공명영상 예비 연구

• 영문명: Deficit in Gender Discrimination Related Circuit in Nonaffected Siblings of Schizophrenia Patients： Preliminary Functional MRI Study
• 발행기관: 대한신경정신의학회
• 저자명: 최경숙 정범석 김지웅 최지욱
• 간행물 정보: 『신경정신의학』제48권 제2호, 70~76쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2009.03.30

영문 초록

Objectives A neural circuit including amygdala, the hippocampal complex and prefrontal cortex was associated with deficits in facial processing in schizophrenia. These deficits have a significant impact on social functioning in schizophrenia. Both neuropsychological deficits and brain structural abnormalities in first-degree relatives of schizophrenia patients suggest that they may also have the deficit in facial information processing as genetic factors. The purpose of this study was to explore the dysfunction of facial information processing in first-degree relatives of schizophrenia patients using functional magnetic neuroimaging (fMRI). Methods Ten non-affected siblings of schizophrenic patients and 10 normal comparison subjects having no schizophrenic siblings underwent fMRI during the dynamic facial change procedure consisting of presentations of facial emotion and gender discrimination stimuli. The emotion discrimination condition consisted of the presentation of 12 happy faces and 12 disgust/fear faces. The gender discrimination condition consisted of the presentation of 12 male faces and 12 female faces. Condition-specific brain activations were compared between non-affected siblings and normal comparison subjects Results The facial information processing related brain regions including fusiform gyrus, several areas of frontal, temporal, occipital, and cerebellar regions exhibited more activation during gender discrimination than emotion discrimination tasks in each group. During gender discrimination task, siblings of schizophrenic patients showed less activation in right fusiform gyrus, both middle and superior frontal gyrus, left cuneus, and left inferior frontal gyrus, compared with normal comparison subjects. Conclusion Dysfunctional facial information processing, such as a deficit in gender discrimination, might be an endophenotype of schizophrenia

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키워드

Schizophrenia Nonaffected siblings fMRI Face discrimination Fusiform gyrus