높은 초조 또는 낮은 초조 증상을 경험하는 정신분열병 급성기 입원환자의 아리피프라졸 치료 효과

• 영문명: Aripiprazole Effects in Patients with Acute Schizophrenia Experiencing Higher or Lower Agitation
• 발행기관: 대한신경정신의학회
• 저자명: 이광헌 사공정규 신지현 한영훈
• 간행물 정보: 『신경정신의학』제48권 제4호, 320~327쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2009.07.30

영문 초록

Objectives The purpose of this study was to investigate the efficacy and predictors of response to aripiprazole treatment in acute schizophrenic patients. We investigated whether baseline agitation level influences the treatment response, and examined the effects of oral aripiprazole in acute patients with schizophrenia experiencing either higher or lower levels of agitation. Methods In this 8-week non-comparative clinical trial, 19 patients with a DSM-IV diagnosis of acute schizophrenia were enrolled. They were divided into groups experiencing higher or lower agitation at baseline. PANSS scores, CGI scores, GAF scores, and PANSS-EC score were used for efficacy assessments. Results 63.2% of patients completed the study. The average dosage of aripiprazole was 26.2± 4.8 mg. Treatment with aripiprazole resulted in significant improvement from baseline in all efficacy measures. In both the higher and lower groups, aripiprazole treatment produced significantly lower PANSS total and PANSS-EC scores, compare with baseline. Moreover, these significant improvements were sustained throughout a 8-week period. A shorter duration of the present episode is associated with a better clinical response. Extrapyramidal symptoms were observed in 36.8% of patients; however, the side effects did not influence the treatment response. Conclusion High doses of aripiprazole significantly improved acute symptoms of schizophrenia irrespective to baseline agitation level, without any significant adverse event. These results suggest that aripiprazole is an effective and safe treatment option for patients with acute schizophrenia who manifest agitation symptoms.

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키워드

Aripiprazole Acute schizophrenia Efficacy Agitation