우울증 환자의 혈액에서 측정되는 BDNF 농도 변화와 그 의미

• 영문명: The Meaning of BDNF Level Measured in Blood of Depressed Patients
• 발행기관: 대한신경정신의학회
• 저자명: 이분희 김용구
• 간행물 정보: 『신경정신의학』제48권 제4호, 203~206쪽, 전체 4쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2009.07.30

영문 초록

Brain-derived neurotrophic factor (BDNF) is an important member of the neurotrophic factors, which are critical regulators of the formation and plasticity of neuronal networks. BDNF is abundant in the brain and periphery and it is found in both human serum and plasma. Stressed animals and depressed patients show reduced BDNF expression in the hippocampus and this reduction can be prevented by antidepressant drug treatment. Recent several clinical studies have indicated the decreases of serum or plasma BDNF levels in untreated patients with major depression. These decreases of BDNF can recover after antidepressant treatment. Increasing BDNF after antidepressant treatment could result from improving depressive symptoms, not just from antidepressant treatment. BDNF can play a critical role in the action mechanism of antidepressant treatment. Taken together, major depression may be considered a dysfunction of critical neuronal networks, and the gradual network recovery may induce antidepressant effect. Serum or plasma BDNF levels could indirectly show the above processes of major depression

목차

서 론

BDNF와 스트레스

BDNF와 우울증

우울증의 신경영양인자 가설 (Neurotrophic Hypothesis)

결 론

REFERENCES

키워드

Brain-derived neurotrophic factor Depression Antidepressant