기억상실성 경도인지장애 환자의 신경정신 증상

• 영문명: Neuropsychiatric Symptoms in Patients with Amnestic Mild Cognitive Impairment
• 발행기관: 대한신경정신의학회
• 저자명: 안인숙 김도관
• 간행물 정보: 『신경정신의학』제48권 제4호, 220~224쪽, 전체 5쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2009.07.30

영문 초록

Objectives To define the neuropsychiatric features of amnestic-type Mild Cognitive Impairment (aMCI) and compare them with those of mild Alzheimer’s disease (AD). Methods The study participants included 353 aMCI and 500 mild AD patients. The Neuropsychiatric Inventory (NPI) was used to assess the neuropsychiatric symptoms in two groups. Results 65.4% of aMCI and 85.4% of mild AD patients exhibited neuropsychiatric symptoms. The most common symptoms in the aMCI group were depression (33.7%), irritability (29.5%), sleep/ night-time behavior (23.2%), apathy (21.5%), and anxiety (21.2). The most common features in the mild AD group were depression (52.4%), apathy (52%), irritability (41.6%), and anxiety (41%). There were significant differences between the aMCI and mild AD groups in 11 NPI symptoms except sleep/night-time behavior. Conclusion A high prevalence of neuropsychiatric symptoms were associated with aMCI, especially mood disturbances and apathy. In contrast, psychotic symptoms were rare. The neuropsychiatric symptoms observed in aMCI were similar to those of mild AD.

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키워드

Mild Cognitive Impairment (MCI) Neuropsychiatric symptoms Neuropsychiatric Inventory(NPI)