노인인구에서 인지기능과 혈청지질농도의 연관성

• 영문명: A Correlation between Neurocognitive Function and Serum Lipid Levels among the Korean Elderly
• 발행기관: 대한신경정신의학회
• 저자명: 윤성욱 김승진 이정구 백준형 전동욱 문정준 김정은 이상경 김영훈
• 간행물 정보: 『신경정신의학』제48권 제6호, 430~436쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2009.11.30

영문 초록

Objectives In this study, we evaluated the correlation between neurocognitive function and serum lipids levels among Koreans over 60 years old. Also, we investigated the sociodemographic risk factors and vascular risk factors in Alzheimer’s disease. Methods Six hundred fifty elderly persons participated in this study. We screened for cognitive impairment via the Mini-Mental Status Examination-Korean version (MMSE-KC) and evaluated 181 participants using the Consortium to Establish a Registry for Alzheimer’s disease, Korean version (CERAD-K). For further classification, we employed the Clinical Dementia Rating Scale (CDRS) and DSM-IV diagnostic criteria. Participants having a CDRS score of 1 or more were diagnosed as having Alzheimer’s disease. Results We diagnosed 38 participants as having Alzheimer’s disease, 67 participants as having mild cognitive impairment, and 76 participants as having no cognitive impairment. There were significant differences among the groups with regard to age, education, history of diabetes mellitus medication, history of head trauma, history of CVA, and Hachinski ischemic score (p<0.05). The mild cognitive impairment group showed inverse correlations between triglyceride serum level and both total MMSE-KC score and Orientation in MMSE-KC (rs=-0.267, p=0.029；rs=-0.324, p=0.007). This group also showed inverse correlations between total cholesterol serum level and both total MMSE-KC score and Orientation in MMSE-KC (rs=-0.259, p=0.034；rs=-0.417, p=0.000) and an inverse correlation between low density lipoprotein serum level and Orientation in MMSE-KC (rs= -0.320, p=0.008). Conclusion There were inverse correlations between some lipids serum levels and cognitive functions in the mild cognitive impairment group

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키워드

Alzheimer’s disease Mild cognitive impairment Serum lipid profile Risk factors Neurocognitive function