한국인 정신분열병 환자에서 COMT 유전자내의 단일염기 다형성 분석

• 영문명: Analysis of Single Nucleotide Polymorphisms of COMT Gene in Korean Schizophrenics
• 발행기관: 대한신경정신의학회
• 저자명: 이동기 김성환 최병무 박재홍 손성락 강호진 홍영습
• 간행물 정보: 『신경정신의학』제49권 제2호, 201~209쪽, 전체 9쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2010.03.30

영문 초록

Objectives Catechol-O-methyltransferase (COMT) plays an important role in metabolizing catecholamines, including dopamine. Also, several single-nucleotide polymorphisms (SNPs) of the COMT gene are associated with schizophrenia. Therefore, this study aimed to find the association between COMT gene SNPs and schizophrenia in Koreans. Methods Participants were 366 schizophrenia patients and 359 normal controls. To identify the SNPs, we performed genetic analyses in 4 SNP regions, via SNP-ITTM assays. We compared allele, genotype, and haplotype frequencies between the two groups. Moreover, we built subgroups, based on onset age, and compared individual allele and genotype frequencies among these subgroups. Results In female patients, genotype frequencies showed a significant difference in rs2020917 among the 4 SNPs (p=0.0224), but haplotype frequencies showed no such difference among the 4 SNPs between patients and controls. We noted a significant difference in rs1544325 allele frequencies according to onset age. Also, in female patients, rs1544325 allele and genotype frequencies varied significantly according to onset age. Conclusion This study found no genetic association between the COMT gene’ s 4 SNPs and schizophrenia in Koreans. However, our findings suggest genetic components for sex-specificity and onset age in Korean schizophrenics

목차

서 론

방 법

결 과

고 찰

결 론

REFERENCES

키워드

Schizophrenia SNPs COMT gene Allele Genotype Haplotype Association study