급성기 후 보행 가능한 경도 혹은 중등도의 외상성 뇌손상 환자에서 심박동 변이도 분석을 이용한 자율신경 기능의 평가

• 영문명: Assessment of Autonomic Function in Post-Acute Ambulatory Patients with Mild or Moderate Traumatic Brain Injury Using the Analysis of Heart Rate Variability
• 발행기관: 대한신경정신의학회
• 저자명: 안준형 이진영 김종훈
• 간행물 정보: 『신경정신의학』제49권 제4호, 374~382쪽, 전체 9쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2010.07.30

영문 초록

Objectives Autonomic nerve system dysfunction has been reported in patients following traumatic brain injury (TBI). However, studies providing direct evidence of a link between the two have been scarce. The purpose of the present study was to evaluate cardiac autonomic modulation in post-acute ambulatory outpatients with TBI using an analysis of heart rate variability (HRV). Methods Twenty-one patients with TBI and 21 age- and gender- matched normal controls were evaluated. The HRV assessments were performed using conventional time and frequency domain analyses as well as non-linear complexity analysis. Results In the patient group, standard deviation values of the RR intervals (SDNN), the square root of the mean squared differences of successive normal sinus intervals (RMSSD), total successive RR interval difference (TSRD), and the very low frequency (VLF) power spectral parameter were significantly lower than in the control group. The patients with moderate severity of TBI exhibited a significantly lower value of VLF than those with mild severity. The severity of anxiety symptoms had a tendency to be correlated with the mean heart rate and the ratio of low-to-high frequency spectral power. Conclusion The results of the present study provide evidence that TBI is associated with reduced HRV, suggesting the critical involvement of central autonomic structures in the pathogenesis of TBI. The HRV measures may serve as an index for monitoring aspects of autonomic function in patients with TBI.

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키워드

Traumatic brain injuries Autonomic nervous system Heart rate variability