정상 노화에 따른 정량화 뇌파와 Current Source Density 변화

• 영문명: Age Differences of Quantitative Electroencephalography and Current Source Density
• 발행기관: 대한신경정신의학회
• 저자명: 성경애 이승환 김상래
• 간행물 정보: 『신경정신의학』제50권 제5호, 401~408쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2011.09.30

영문 초록

Objectives Age-related differences of the brain have been obtained by various methods. This study was aimed to explore the changes of quantitative electroencephalography (qEEG) and their source localization in normal aging. Methods Thirty-seven healthy young adults (mean age 35.22±13.62 years) and thirty-nine cognitively-healthy elderly subjects (mean age 72.95±5.73 years) participated in the study. Resting-state EEGs were recorded while subjects were in a relaxed state. Relative qEEG powers of five frequency bands were analyzed for eye closed conditions: delta (1-3 Hz), theta (4-7 Hz), alpha (8-12 Hz), beta (13-25 Hz), and gamma (30-50 Hz). The standardized low resolution electromagnetic tomography (sLORETA) was used to identify the current source densities of each frequency band. Results The elderly group showed an increase of beta and gamma power while the reduction of delta, theta, and alpha power compared with the young group. Controlling education as a covariate, the beta power was positively correlated with age, while theta power was negatively correlated with age in all subjects. sLORETA revealed that elderly subjects had reduced current source density at the cingulate gyrus in the theta band, while increased current source densities at the frontal, parietal, insula, and limbic areas in the beta band compared with young adults. Conclusion Our results suggested that qEEG could reflect normal aging. Cognitively healthy elderly subjects showed an increase of high-frequency power, while showing a reduction of low-frequency power. These functional implications were discussed.

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키워드

qEEG sLORETA Normal aging Current source density