Toloxatone의 항우울 효과에 대한 임상연구

• 영문명: A Clinical Study of Antidepressant Effect of Toloxatone
• 발행기관: 대한신경정신의학회
• 저자명: 사공정규 박형배 정성덕
• 간행물 정보: 『신경정신의학』제33권 제1호, 249~255쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1994.01.30

영문 초록

The authors conducted an open-trial clinical study to evaluate the clinical efficacy of toloxatone, a reversible inhibitor of MAO-A. The study group were 8 6 patients with either DSMIII- R diagnosis of major depression or dysthymia, who visited the Department of Psychiatry College of Medicine, Yeungnam University during the period from January to July 1992 and each patient received toloxatone(600mg/day) for 28 days. The clinical effect of toloxatone were evaluated using the Hamilton Rating Scale for Depression, weekly by two psychiatrists. The results were as follows : 1) There was statistically significant improvement on the Hamilton Rating Scale for Depression after 7 days treatment(p<0.01). 2) Side effects were excitement and insomnia, gastrointestinal effects, drowsiness, dizziness, anticholinergic effects and facial edema in a few patient, but were tolerable. 3) In all subjects, hypertensive reaction was not observed without food restriction and blood pressure did not show any differences

목차

서 론

대상 및 방법

결 과

고 찰

결 론

참 고 문 헌

키워드

Toloxatone Depression Hypertension