정신분열증의 음성증상에 대한 카페인의 치료효과

• 영문명: Therapeutic Effect of Caffeine on the Negative Symptoms of Schizophrenia
• 발행기관: 대한신경정신의학회
• 저자명: 김홍근 김상욱 김명정
• 간행물 정보: 『신경정신의학』제33권 제1호, 232~239쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1994.01.30

영문 초록

The effect of caffeine on the negative symptoms of schizophrenia was studied. Twenty three schizophrenics of the negative type were treated with caffeine and placebo in a double blind cross-over design. For a period of 5 weeks, the symptoms were evaluated using Positive and Negative Syndrome Scale, Scale for the Assessment of Negative Symptoms and Negative Symptom Rating Scale. The results were as follows : 1) The negative symptoms improved significantly after one day of caffeine administration in all three scales of the measurement and this effect continued up to 7days of caffeine administration in two scales out of three. This effect however disappeared after 2 weeks of caffeine treatment in all three scales. 2) No significant effect was observed in positive scores and general psychopathology scores of Positive and Negative Syndrome. The above results suggest that caffeine has only transient therapeutic effect on negative symptoms of schizophrenia.

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키워드

Schizophrenia Negative symptom Caffeine Dopamine