精神分裂病에서 腦 磁氣共鳴映像의 形態測定學的 研究

• 영문명: A Morphometric Study of Magnetic Resonance Brain Images in Schizophrenia
• 발행기관: 대한신경정신의학회
• 저자명: 田珍淑
• 간행물 정보: 『신경정신의학』제33권 제4호, 904~916쪽, 전체 13쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1994.07.30

영문 초록

Since Johnstone et al(1976) had discovered ventricular enlargement in the CAT scans of chronic schizophrenics, structural brain abnormalities have been focus of interest in relation with the pathophysiology of schizophrenia. In this study, some neuroanatomical structures presumed to be involved in schizophrenia were evaluated in the MRIs of 13 schizophrenics in comparison with 15 neurotic controls. All MRI scans were obtained with a 1.0T SMT-100 scanner using high-resolution spine echo technique, with 5mm contiguous sections in T1-weight ed sagittal plane (TR/TE=500ms/20ms) and 7mm contiguous sections in T2-weighted coronal plane(TR/TE= 3,000ms/90ms). Transferring the raw data stored in the magnetic tape to the optical disk, the area and the mean of the image signal intensity、of free ROIs including prefrontal cortex, corpus callosum, amygdala-hippocampal complex, septum pelluddum, thalamus, caudate and lentiform nuclei, and cerebellum were measured by the image analysis system. In schizophrenics, as compared with controls, the area of septum pelluddum was insignificantly larger, and the area of thalamus(P

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키워드

Left prefrontal cortex Amygdala-hippocampal complex Thalamus Cerebellum

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