스트레스로 유발된 흰쥐의 면역억제에 대한 날록손의 영향

• 영문명: Effect of Naloxone on Stress-Induced Immunosuppression in Rat
• 발행기관: 대한신경정신의학회
• 저자명: 윤충한 김정목 류재욱 김시현 김현택 양병환 김광일
• 간행물 정보: 『신경정신의학』제34권 제3호, 858~871쪽, 전체 14쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1995.05.30

영문 초록

Objects : The present study addressed the effects of stress upon an opiate-mediated immuno suppression. Method : Male Sprag-Dawley rats were used as subjects. Home cage control group had no stress condition and Skinner box control group was immobilized without electric shock. Conflict group received psychological conflict stress with electric shock depending on the coping b e h a viour. Pretreatm ent groups had received naloxone intraperitoneally and 15minutes later, received psychological conflict stress. And the natural killer cell cytotoxicity(N K C C ) against YAC-1 murin elymphoma cells, proliferation of rat splenic lym phocytes stimulated with mitogen such as concanavalin-A a n d plasm a concentration of corticosterone were measured. Results : The results show that exposure to stress produces significant decline in N K C C an d lym phocyte proliferation, which are reversed by opioid antagonist( naloxone) and increase in plasm a concentration of corticosterone in all experim ental groups. Conclusion : Opioid system may play a major role in the modulation of the stress-induced immunosuppression

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연구대상 및 방법

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참고문헌

키워드

Stress Immunosuppression Opioid system Naloxone