알쯔하이머병의 말초 생물학적 지표로서 혈청 Alpha-1-antichymotrypsin

• 영문명: Serum Alpha-l-antichymotrypsin Concentration as a Peripheral Biological Marker in Alzheimer’s Disease
• 발행기관: 대한신경정신의학회
• 저자명: 우종인 이정희 주진형
• 간행물 정보: 『신경정신의학』제35권 제6호, 1467~1475쪽, 전체 9쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1996.11.30

영문 초록

Objectives : The authors measured serum alpha-1 -antichymotrypsin(ACT) level to elucidate its possibility to be a peripheral marker in Alzheimer s disease(AD) and to examine its relationship with aging. Methods : The subjects were 19 AD patients(age ： 71.9 土7.6，range : 55 - 89) diagnosed by NINCDS-ADRDA criteria, 8 vascular dementia(VD) patients(age ： 72.5±9.4，range ： 56-85), 32 normal control subjects(age ： 42.4土21.4，range ： 21-82). Serum ACT levels were determined with radial immunodiffusion plates purchased from the Binding Site after 72-hour incubation. Results ： The serum ACT levels of AD patients were not significantly different from those of old control(OC) subjects(age ： 70.9 ±4.6 range ： 66 - 82), but ACT levels of VD patients were significantly higher than those of OC subjects(p〈0.05). And there was significant correlation between ACT levels and age(r=0.5820，p<0.01). Conclusions ： These results suggest that the increment of serum ACT level appears to be associated with the vascular component in dementia patients as well as with normal aging factor. However, its possibility to be a peripheral marker of AD seems to be low

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Alpha-l-antichymotrypsin Alzheimer s disease Vascular dementia Aging process