Fluphenazine , Lithium 및 L- dopa 가 가토 혈중 주정농도에 미치는 영향에 관한 실험적 연구

• 영문명: EFFECTS OF FLUPHENAZINE, LITHIUM AND L- DOPA ON BLOOD ALCOHOL LEVEL IN RABBITS
• 발행기관: 대한신경정신의학회
• 저자명: 주문희
• 간행물 정보: 『신경정신의학』제13권 제4호, 466~474쪽, 전체 9쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1974.10.30

영문 초록

Lithium has lately been regarded as an extremely promising psychotropic drug in treatment of mania, various psychotic excitements and recurrence of both manic and depressive symptoms. Fluphenazine, which is a potent and long acting phenothiazine derivatives, has been used in treatment of the ambulatory and chronic schizophrenic patients who need prolonged and continuous psychotropic medi- cation. It has been known that L-dopa is of pa- rticular value in controlling Parkinsonism by increasing the concentration of doparaine in basal ganglia. In I960, Khouw et al. reported that chlorpromazine elevated the blood alcohol level in horse by the inhibition of alcohol dehydrogenase (ADH) in liver. Other investigators have also been latelyreported that lithium， some antidepressants and several psychotropic drugs elevated the blood alcohol level in rabbits. In view of these findings, the author conducted an animal experiment to investigate the effects of fluphenazine alone, in combination with lithium, and L-dopa alone on blood alcohol level in rabbits. Materials and Methods 1. The experimental work was done with mature rabbits of both sexes, weighing between 2.0kg to 3.0kg. 2. The experimental animals -were divided into two groups; control and experimental group. Control group was given alcohol alone, and experimental group was further divided into four groups; alcohol+fluphenazine group, alcohol+lithium group, alcohol+L-dopa group and alcohol+.fluphenazine+ lithium group. 3. | luphenazine was given orally. Alcohol+flupheifSzine group was divided into two subgroups. In the first subgroup was given 1.0mg/kg of body weight, daily for five days, and in the second subgroup, 2. Omg/kg of body weight, daily for five days. The last dose of fluphenazine was given 90 minutes before alcohol administration. 4. L-dopa was given orally, in a dose of 500mg/kg of body weight, daily for five days. The last dose of L-dopa was given 90 minutes before alcohol administration. 5. Lithium chloride solution, 6.36%, was given in a dose of 3- 0mEq/kg of body weight, daily for four days by intravenous route. The last dose was given 60 minutes before alcohol administration. 6. In all groups, 20 vol. % ethanol solution was given, in a dose of 5- Oml/kg of body weight, at a constant rate for five minutes, by intravenous route. 7. All of the blood specimens were obtained by cardiac puncture at 15 and 45 minutes respectively after alcohol administration. 8. The blood alcohol level was determined by Cavett’s method. Results 1. Alcohol+fluphenazine group In the first subgroup, fluphenazine elevated the blood alcohol level at both 15 and 45 minutes after alcohol administration. But, at 15 minutes, the result was not statistically significant ( P >0.05). In the second subgroup, fluphenazine elevated the blood alcohol level significantly at both 15 and； 45 minutes after alcohol administration (F< 0.01). 2. Alcohol+lithium group Lithium elevated the blood alcohol level significantly at both 15 (P < 0.0 1) and 45 minutes ( F < 0.02) after alcohol administration. 3. Alcohol+L-dopa group L-dopa lowered the blood alcohol level at both 15 and 45 minutes after alcohol administration. However, the result at 15 minutes was not statistically siginificant (P < 0 .0 5 ). 4. Alcohol+fluphenazine+lithium group Fluphenazine combined with lithium elevated significantly the blood alcohol level at both 15 and 45. minutes after alcohol administration( P <0.01). The blood alcohol levels of this group were significantly higher than those of all subgroups of alcohol+ fluphenazine and alcohol+lithium group. Conclusions 1. The orally administered fluphenazine, in a dose of 1. Omg/kg/day, for 5 days and, in adose of 2. Omg/kg/day, for 5 clays elevated the blood alcohol level in rabbits at both 15 and 45 minutes after alcohol administration. But, at 15 minutes after administration of 1. Omg/kg/day for 5 days, the result was not signi

목차

서 론

실험재료 및 방법

실 험 성 적

고 찰

결 론

참 고 문 헌