Lithium 및 Perphenazine 이 가토 혈중 주정농도에 미치는 영향에 관한 실험적 연구

• 영문명: EFFECTS OF LITHIUM AND PERPHENAZINE ON BLOOD ALCOHOL LEVEL IN RABBITS
• 발행기관: 대한신경정신의학회
• 저자명: 유순형
• 간행물 정보: 『신경정신의학』제14권 제4호, 436~443쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1975.10.30

영문 초록

Lithium has lately been regarded as an extremely promising psychotropic drug in treatment of mania and various psychotic excitement. Perphenazine, which is a strong anti-emetics and particularly effective for schizophrenia, is one of the most extensively used phenothiazines. In 1960, Khouw et al. reported that chlorpromazine elevated the blood alcohol level in horse by the inhibition of alcohol dehydrogenase (ADH) in liver. Other investigators has recently reported that lithium, some antidepressaats and several psychotropic drugs elevated the blood alcohol level in rabbits. In view of these findings, the author conducted an animal experiment to investigate and evaluate the effects of perphenazine alone and in combination with lithium on blood alcohol level in rabbits. Material and Methods 1. The experimental work was done with mature rabbits of both sexes, weighing between 2. 0kg to 3 .0kg. 2. The experimental animal were divided into two groups; control and experimental group. Control group was given alcohol alone, and experimental group was further divided into three groups； alcohol+perphenazine group, alcohol+lithium group and alcohol+perphenazine+lithium group 3. Lithium chloride solution (6.36%) was given intravenously. Alcohol-f-lithium group was divided into two subgroups. In the first subgroup, lithium was given 3.0 mEq/kg of body weight, daily for 4 days, and in second subgroup, daily for 7 days. The last dose of lithium was given 60 minutes before alcohol administration. 4. Perphenazine was given intraperitoneally, in a dose of 4mg/kg of body weight, daily for 5 days. The last dose was given 60 minutes before alcohol administration. 5. In perphenazine and lithium group, perphenazine was given intraperitoneally, in a dose of 4mg /kg of body weight, daily for 5 days, and lithium chloride solution (6.36%) was given intravenously, in a dose of 3mEq/kg of body weight, daily for 4 days. The last one was given 60 minutes before alcohol administration. 6. In all groups, 20 vol. % alcohol was given, in a dose of 5. Oml/kg of body weight, at a constant rate for 5 minutes, by intravenous route. 7. All of the blood specimen were obtained by cardiac puncture at 15 minutes and 45 minutes respectively after alcohol administration. 8. The blood alcohol level was determined by Cavett’s method. Result 1. Alcohol+perphenazine group Perphenazine elevated the blood alcohol level significantly at both J5 (P<. 01) and 45 minutes (P< . 01) after alcohol administration. 2. Alcohol+lithium group In both subgroups, lithium elevated significantly the blood alcohol level at both 15 (P< . 01) and 45 minutes (P<. 01) after alcohol administration. 3. Alcohol+perphenazine-f lithium group Perphenazine combined with lithium elevated significantly the blood alcohol level at both 15 (P <• 01) and 45 minutes (P<. 01) after alcohol administration. In this group, blood alcohol levels were significantly higher than those of the subgroup of alcohol+perphenazine and of alcoh이+ lithium (for 4 days), but there was no significant change in blood alcohol level between this one and ale oh ol 4- lithium (for 7 days) at both 15 (P>. 05) and 45 minutes (P> . 05) after alcohol administration. Conclusion 1. Intravenus injection of lithium chloride (in a dose of 3.0 mEq/kg/day, for both 4 days and 7 days) elevated significantly the blood alcohol level in rabbits at both 15 and 45 minutes after alcohol administration. 2. Intraperitoneally injected perphenazine, elevated significantly the blood alcohol level in rabbits at both 15 and 45 minutes after alcohol administration. 3. The perphenazine combined with lithium chloride elevated significantly the blood alcohol level in rabbits at both 15 and 45 minutes after alcphol admmistration,

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