정신분열병 환자의 임상반응에 따른 혈장 Homovanillic Acid와 혈장 할로페리돌의 변화

• 영문명: Plasma Homovanillic Acid and Plasma Haloperidol Level Changes According to the Clinical Responses in the Schizophrenics
• 발행기관: 대한신경정신의학회
• 저자명: 구자일 오동열 양병환
• 간행물 정보: 『신경정신의학』제31권 제1호, 28~41쪽, 전체 14쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1992.01.30

영문 초록

Nineschizophrenic inpatients were studied under haloperidol treatment for the purpose of evaluating the possible correlation between plasma HVA, leuelsCP-HVA) plasma haloperidol levels (P-haloperidal) and clinical symptom changes. The authors measured plasma HVA and plasma haloperidol levels, and checked BPRS and SAPS scores at baseline，7th day, 28th day and 56th day of treatment. 1) P-HVA concentrations of total patients were highest on 7th day, then returned to baseline levels on 28th day，but that of drug responder group(6 patients) were highest on pretreatment then decreased below baseline levels on 7th day and continued to decrease till 56th day of treatment. 2) P-HVA concentrations of total patients showed positive correlations with BPRS scores (r=0.28, p<0.1) and with SAPS scores(r=0.36，p

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