24시간 혈중농도와 신배설률을 이용한 리툼 치료량 예측법의 평가비교

• 영문명: A Comparison Between the 24 Hour Serum Level and the Renal Clearance to Predict Therapeutic Lithium Dose
• 발행기관: 대한신경정신의학회
• 저자명: 김진세 정인과 곽동일
• 간행물 정보: 『신경정신의학』제31권 제4호, 708~715쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1992.07.30

영문 초록

Cooper’s method using 24 hour serum lithium level and Normans method using renal lithium clearance after a single loading dose were compared to determine which predicted therapeutic lithium dose better. The author concluded the Norman’s method was superior after evaluating the accuracy, the rapidity, and the utility of the two methods. And the author suggest the availabilty of the predicting methods to overcome the limitations of lithium therapy, such as the Harrow range of therapeutic level, the time-consumption reaching therapeutic level, and the individual variation of therapeutic dose. The summary of results were as follows: 1) In Cooper’s method, the objects included in the acute therapeutic level, 0.80〜 1.20mEq/l， were only 10 of 19 objects after taking prdeicted lithium dose. 2) In Norman’s method, the objects included in the acute therapeutic level were all of 19 objects, and the actual serum lithium level, 0.80〜 1.15mEq/K were predicted with average error ±4.89%.

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