優戀症에서 甲狀腺 Hormones와 Prolactin의 相互作用

• 영문명: Interaction of Thyroid Hormones and Prolactin in Depression
• 발행기관: 대한신경정신의학회
• 저자명: 田珍淑
• 간행물 정보: 『신경정신의학』제31권 제4호, 681~688쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1992.07.30

영문 초록

The early studies on the neuroendocrine hormones which are related to the pathogenesis of depression were focused on the hypothalamic-pituitary-adrenal axis, and then on the hypothalamic- pituitary-thyroid axis. However, recently hormones other than corticosteroids and thyroid hormones are suggested to be possibly related. Most of all, prolactin is known to influence the hypothalamic-pituitary-thyroid axis and to be involved with the control of its interacion. Previously, I had reported the experience of two cases with hyperprolactinemia secondly to the hypothyroidism accompanied by depression (Cheon 1991). By expanding the subject materials, this subsidiary study was tried to evaluate whether there is statistically significant changes in the thyroid hormones and prolactin levels in many depressed patients. Using Quanticoat Radioimmunoassay Kit, the T3 and T4 levels were quantitatively measured in 42 depressed patients who visited Department of Neuropsychiatry, Dong-Eui University Medical Center from early November, 1990 till late May, 1991. They scored over 10 in BDI, 12 in HDS and 16 in CES-D. Serum TSH levels were measured using TSH IRMA [125I] Coated Tube Immunoradiometric Assay Kit (Spectra). And serum prolactin levels were measured using Allegro Prolactin Immunoassay Kit There is no significant change in T3 and T4 levels. However, TSH levels decreased significantly (P<0.01), and prolactin levels increased significantly(P<0.005) as compared to the control values. However, correlation between prolactin and thyroid hormones couldn’t be found. Furthermore, their concentrations were not correlated with age, sex and severity of depression. In conclusion, some kind of dysfunction in thyroid hormones and prolactin seemed to be involved in the pathogenesis of depression, possibly via the interaction with serotonergic and dopaminergic mechanisms

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