부자추출물의 골격근 세포에서의 에너지 조절 작용

• 영문명: Effect of Aconitum carmichaeli Debx on Energy Metabolism in C2C12 Skeletal Muscle Cells
• 발행기관: 한방비만학회
• 저자명: 송미영(Mi young Song)
• 간행물 정보: 『대한한방비만학회지』제16권 2호, 109~115쪽, 전체 7쪽
• 주제분류: 의약학 > 한의학
• 파일형태: PDF
• 발행일자: 2016.12.31

영문 초록

Objectives: The all anti-obesity drugs currently approved by the US Food and Drug Administration work by reducing energy intake. In fact, no approved drug targets energy expenditure. In Korean medicine, it is known to Qi or Yang invigorating therapy could increase energy metabolism. Aconitum carmichaeli Debx (ACD) is a Yang invigorating herb, often used for treat obesity in Korean medicine. In the present study, the authors investigated the regulatory effects of ACD in energy metabolism and mitochondrial biogenesis in C2C12 skeletal muscle cells. Methods: The water extract of ACD (0.2, 0.5 and 1.0 mg/ml) were treated in differentiated C2C12 cells. The protein or mRNA levels of target genes were analyzed and mitochondrial mass were investigated. Results: ACD activated the expressions of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), nuclear respiratory factor 1 and TFAM and increased mitochondrial mass. ACD also increased adenosin monophosphate-activated protein kinase (AMPK), and acetyl-CoA carboxylase. Conclusions: This study suggests that ACD has the potential to increase energy metabolism and mitochondrial biogenesis by activating AMPK and PGC1α.

목차

서 론

재료 및 방법

결과 및 고찰

감사의 글

References

키워드

Aconitum carmichaeli Debx Peroxisome proliferator-activated receptor gamma coactivator 1-alpha AMP-activated protein kinases Energy metabolism C2C12