돌콩추출물의 db/db 비만마우스에서의 항당뇨효능 연구

• 영문명: Anti-Diabetic Effects of Glycine soja Extract in Genetic Animal Model of db/db Mouse
• 발행기관: 한방비만학회
• 저자명: 최정준(Jeong June Choi)
• 간행물 정보: 『대한한방비만학회지』제16권 2호, 101~108쪽, 전체 8쪽
• 주제분류: 의약학 > 한의학
• 파일형태: PDF
• 발행일자: 2016.12.31

영문 초록

Objectives: This study is aim to investigate the anti-diabetic effects of Glycine soja Siebold et Zucc. (GS) in diabetic mellitus animal model. Methods: Male BKS.Cg-m＋/＋ Leprdb/J mice (db/db mice) randomly assigned to 3 groups and treated with saline, metformin (150 mg/kg/day, positive control), and GS extract (2 g/kg/day). Body weight, food intake, and fasting blood glucose were monitored every week. After a conse-cutive 6-week treatment, the levels of lipid metabolites and insulin in plasma were measured with biochemistry analyzer. Results: As well as fasting blood glucose and food intake, the levels of triglyceride, total cholesterol, and low-density lipoprotein in plasma were also dramatically decreased in GS group. Also, GS extract administration decreased the total fat mass. However, GS extract could not change the level of high-density lipoprotein and insulin. Furthermore, there was no difference in body weight between control and GS extract-treated group. Conclusions: GS may have a potential to ameliorate diabetes mellitus by improving fasting blood glucose level and lipid metabolites. Further studies are warranted to investigate the underlying molecular mechanism of GS.

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키워드

Legumes Diabetes mellitus Blood glucose Lipoprotein Soybeans