청피의 항염증효과

• 영문명: Effects of Citri Reticulatae Viride Pericarpium on 4-Hydroxynonenal-Induced Inflammation in PC12 Cells
• 발행기관: 한방비만학회
• 저자명: 예영준(Young Jun Ye) 김연섭(Youn Sub Kim) 강미숙(Mi Suk Kang)
• 간행물 정보: 『대한한방비만학회지』제16권 2호, 79~84쪽, 전체 6쪽
• 주제분류: 의약학 > 한의학
• 파일형태: PDF
• 발행일자: 2016.12.31

영문 초록

Objectives: The purpose of this study was to observe the effects of Citri Reticulatae Viride Pericarpium (CP) on 4-Hydroxynonenal (4-HNE)-induced inflammation in PC12 cells. Methods: 4-HNE was treated in PC12 cell to cause inflammatory response, and then treated with CP water extract at 25, 50, and 100 μg/ml. The phosphorylation of Jun N-terminal kinase (JNK) and the expression of NF-кB in PC12 cells were determined by Western blot, respectively. Results: The phosphorylation of JNK was significantly decreased in 4-HNE-stimulated PC12 cell by the treatment of CP extract at 25 μg/ml. The 4-HNE-induced expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-кB) p65 in nuclear of the cells was significantly decreased in PC12 cell by treatment with CP extract at 25, 50, and 100 μg/ml. Conclusions: These results suggest that CP water extract has an anti-inflammatory activity through suppressing the JNK and NF-кB activation.

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키워드

Citri Reticulatae Viride Pericarpium 4-HNE pJNK pNF-кB