고지방ㆍ고탄수화물 식이와 Streptozotocin-유도 당뇨병 흰쥐에서 삼릉추출물의 개선효능 연구

• 영문명: Effects of Spagranii Rhizoma Extract on High FatㆍHigh Sucrose Diet and Streptozotocin Administration-Induced Diabetic Rats
• 발행기관: 한방비만학회
• 저자명: 강안나(An Na Kang) 강석용(Seok Yong Kang) 송미영(Mi young Song) 박용기(Yong ki Park)
• 간행물 정보: 『대한한방비만학회지』제16권 2호, 92~100쪽, 전체 9쪽
• 주제분류: 의약학 > 한의학
• 파일형태: PDF
• 발행일자: 2016.12.31

영문 초록

Objectives: This study was designed to evaluate the anti-diabetic effects of Spargaium stoloniferum Buchanan-Hamilton (Sparganii Rhizoma, SR) extract on diabetic rats. Methods: Diabetes was induced with Sprague-Dawley rats by high fat/high sucrose (HF/HS) diet for 4 weeks and injection of a single low dose of streptozotocin (STZ; 35 mg/kg). SR water extract at 500 mg/kg was orally administrated once a day for 4 weeks. Body weights, food and water intakes and urine volumes were measured. The levels of glucose, insulin, total cholesterol, glutamic oxaloacetic transaminase and glutamic-pyruvic transaminase (GPT) were measured in the sera of rats. Histological changes were observed in pancreas, liver, and kidney tissues by H&E staining. Results: The administration of Sparganii Rhizoma extract at 500 mg/kg in diabetic rats did not shown a significant difference in body weight changes and GPT levels, but showed meaningful changes in an increase of urination volume, and decrease of serum glucose and insulin levels. Total cholesterol and GPT levels were also significantly decreased after SR extract administration in diabetic rats. Furthermore, the abnormal changes of pancreas, liver and kidney were also improved by Sparganii Rhizoma extract administration. Conclusions: These results indicate that SR extract can improve HF/HS-diet and STZ-induced diabetic damages in rats through inhibition of the blood glucose and insulin increase.

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키워드

Spargaium stoloniferum Sparganii Rhizoma High fat/high sucrose diet Streptozotocin Type 2 diabetes mellitus Obesity