비만형 동물모델에서 복합 한약 추출물 CAPA의 비만 및 당대사 개선 효능

• 영문명: The Mixed Herbal Extract, CAPA, Prevents Obesity and Glucose Intolerance in Obese Mice
• 발행기관: 한방비만학회
• 저자명: 송미영(Mi young Song)
• 간행물 정보: 『대한한방비만학회지』제17권 2호, 119~126쪽, 전체 8쪽
• 주제분류: 의약학 > 한의학
• 파일형태: PDF
• 발행일자: 2017.12.31

영문 초록

Objectives: This study investigated the effects of the mixed herbal extract from Cinnamomum cassia Blume, Atractylodes macrocephala Koidzumi, Pueraria lobata Benth, and Aconitum carmichaeli Debx (CAPA) on obesity and glucose tolerance in obese mice. Methods: Animals were divided in 6 groups, normal diet, high fat diet (HFD), HFD with CAPA 100 mg/kg (CAPA 100), CAPA 300 mg/kg (CAPA 300), and metformin 200 mg/kg or lorcaserin 10 mg/kg as positive controls, and treated for 16 weeks. Body weight, food intake, fasting blood glucose, and body temperature were checked every week and then organs, blood serums were collected after treatment. The oral glucose tolerance test was also carried out after treatment. Results: Compared to HFD, CAPA extract treated mice showed significant decreases in body weight, adipose tissue weight, lipid accumulations in liver and serum lipid levels without a reduction of food intake. And fasting glucose and glucose tolerance were all improved in the CAPA treated mice. Conclusions: Our results suggest that CAPA extract can prevent diet induced obesity and glucose intolerance without a reduction of energy intake in obese mice.

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키워드

Cinnamomum cassia Blume Atractylodes macrocephala Koidzumi Pueraria lobata Benth Aconitum carmichaeli Debx Obesity Glucose