삼정환의 랫드를 이용한 단회 경구투여 독성시험

• 영문명: Single Oral Dose Toxicity Study of Modified Samjung-Hwan in Sprague-Dawley Rats
• 발행기관: 한방비만학회
• 저자명: 김민지(Min jee Kim) 이명종(Myeong jong Lee) 김호준(Ho jun Kim)
• 간행물 정보: 『대한한방비만학회지』제17권 2호, 96~100쪽, 전체 5쪽
• 주제분류: 의약학 > 한의학
• 파일형태: PDF
• 발행일자: 2017.12.31

영문 초록

Objectives: Samjung-hwan (SJH) is a Korean herbal formula that has been used for antilipidemic, antioxidant, and antidepressant effects. As a part of safety evaluation, single oral dose toxicity study of modified SJH in Sprague-Dawley (SD) rats was carried out. Methods: Modified SJH extract was administered orally in male and female SD rats at dose of 5,000 mg/kg. After single oral administration of modified SJH, we monitored the changes of mortalities, clinical signs, and body weight daily for 14 days. Gross necropsy findings were also evaluated at the end of the experiment. Results: Modified SJH extract did not induce any toxic signs in the changes of mortalities, clinical signs, and body weight. There were also observed no gross necropsy findings in rats. Conclusions: As results, the approximate lethal dose of modified SJH extract in SD rats was considered to be over 5,000 mg/kg. This suggests that modified SJH is safe herbal formula for the treatment with.

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키워드

Samjung-hwan Safety Single dose toxicity