갈근 추출물이 에스트로겐 결핍 Rat의 비만관련 호르몬에 미치는 영향

• 영문명: Effects of Pueraria lobata on Obesity Related Hormones in Rats with Estrogen Deficiency
• 발행기관: 한방비만학회
• 저자명: 백선은(Seon eun Baek) 백지윤(Ji Yun Baek) 강기성(Ki sung Kang) 유정은(Jeong eun Yoo)
• 간행물 정보: 『대한한방비만학회지』제17권 2호, 111~118쪽, 전체 8쪽
• 주제분류: 의약학 > 한의학
• 파일형태: PDF
• 발행일자: 2017.12.31

영문 초록

Objectives: This study was conducted to evaluate the effects of Pueraria lobata (PL) extract on obesity related hormones in rats with estrogen deficiency. Methods: The experiments were performed with the use of ovariectomized rats as estrogen-deficient obesity rat model. They were grouped Normal (sham operation group), Control (ovariectomy group), 50 mg/kg PL (ovariectomy group＋50 mg/kg of PL), 100 mg/kg PL (ovariectomy group＋100 mg/kg of PL), 200 mg/kg PL (ovariectomy group＋200 mg/kg of PL). PL extract was orally administered for 8 weeks once a day. Body weights and serum levels of hormones, such as leptin, estradiol, cholecystokinin (CCK), ghrelin, and adiponectin were estimated by ELISA. Results: PL extract significantly decreased body weight, the serum levels of leptin in estrogen-deficient obesity rats. PL extract significantly increased the serum levels of estradiol and CCK. However, PL extract did not directly effect on the levels of ghrelin and adiponectin in estrogen-deficient obesity rats. Conclusions: It is concluded that PL extract reduced body weight, and regulate the hormones related to energy metabolism. PL extract decreased the serum levels of leptin. PL extract increased the serum levels of estradiol and CCK. These results indicate that PL might have potentials for treatment of obesity and complications during the menopause caused by estrogen-deficiency.

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키워드

Obesity Pueraria lobata Menopause Estrogens Hormones