소청룡탕 추출물의 당뇨병 질환에서 위장관 운동 기능 개선에 관한 연구

• 영문명: Effects of Socheongryong-Tang, a Traditional Chinese Medicine, on Gastrointestinal Motility Disorders (Diabetic Models) in Mice
• 발행기관: 한방비만학회
• 저자명: 배진수(Jin soo Bae) 김익성(Ik sung Kim) 서병도(Byoung do Seo) 김병주(Byung Joo Kim)
• 간행물 정보: 『대한한방비만학회지』제17권 2호, 61~67쪽, 전체 7쪽
• 주제분류: 의약학 > 한의학
• 파일형태: PDF
• 발행일자: 2017.12.31

영문 초록

Objectives: The purpose of this study was to investigate the effects of Socheongryong-tang, a traditional herbal medicine, on gastrointestinal (GI) motility disorders (inflammatory and diabetic models) in mice. Methods: The in vivo effects of Socheongryong-tang on GI motility were investigated by calculating percent intestinal transit rates (ITR) and gastric emptying (GE) values using Evans Blue and phenol red, respectively, in normal mice and in mice with experimentally induced GI motility dysfunction (GMD). GMD models were induced by acetic acid and streptozotocin. Results: In normal ICR mice, ITR and GE values were significantly and dose-dependently increased by the intragastric administration of Socheongryong-tang (0.0025∼0.25 g/kg). The ITR values (%) of GMD mice were significantly lower than those of normal mice, and these reductions were significantly and dose-dependently inhibited by Socheongryong-tang. Conclusions: These results suggest that Socheongryong-tang is a good candidate for the development of a prokinetic agent that may prevent or alleviate GMD.

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키워드

Traditional medicine Gastrointestinal motility Gastric emptying Streptozotocin Diabetes mellitus