학술논문
Fluphenazine decanoate의 治療經驗 : 安全한 維特治療를 위한 豫備報告
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- 영문명
- CLINICAL EXPERIENCE OF FLUPHENAZINE DECANOATE: A PRELIMINARY REPORT FOR THE SUCCESSFUL M AINTENANCE THERAPY.
- 발행기관
- 대한신경정신의학회
- 저자명
- 金光曰
- 간행물 정보
- 『신경정신의학』제18권 제4호, 449~458쪽, 전체 10쪽
- 주제분류
- 의약학 > 정신과학
- 파일형태
- 발행일자
- 1979.11.30
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국문 초록
영문 초록
Clinical experience of fluphenazine decanoate therapy was reported with special reference to
safety dos? ge regimen for the successful maintenance therapy.
The experiement was conducted by two successive steps; a full dosage regimen during the first half
of the period, and a low dosage regimen during the later half. During the initial phase of trial, full
estimated doses of fluphenazine decanoate were given to 15 schizophrenic patients (9 acute and 6
chronic cases) who had been treated with oral neuroleptics, for converting oral medication to the
depot. Usual dosage was ranged from 0. 5cc (12. 5 mg) to 2cc (50mg). Akathisia with parkinsonian
rigidity was noticed in 13 cases (86.7% ) and moderate and severe degrees of the side effects was seen
in 12 cases(80. 096). Three cases were uncontrollable by high dose of antiparkinsonian agents and bydiscontinuation
of depot injection. This side effect in one case who had been given 2cc of the depot
has persisted over 6 months after the discontinuation. Eighty percent of drop-out rate could be
detected in these cases and the main reason was painful distress of the side effects.
With the above experience the author gave up such a method of conversion and a new dosage regimen
has been tried for the safe use. Oral medication was switched to the depot after acute symptoms
subsided and after considerable improvement ensued when the required dose of fluphenazine decanoate
was less than lcc(25m g). Two hours after initial shot of 0. Ice, an additional 0.1 or 0. 2cc is given
if further dosage is needed with the condition that there is no side effect. When further dosage is
required, the remainder is given on the 7th day with careful evaluation of side effects. The above
dosage regimen has been tried to 30 schizophrenic patients (21 convalescent and 9 chronic cases). Sixty
seven percent was given less than 0 .3cc(7.5mg) and only two cases needed lcc. Fourty three percent
could be reduced in their dosage during maintenance. Intervals of injection were 14 days in 10
percent, 18 days in 3.3 percent, 21 days in 69.7 percent and 28 days in 20 percent. The intervals
could be extended in 20 percent of the cases and was constant in 76.7 percent. Side effects were
noticed in 33.3 percent, but mostly mild and subjective. Only 3 cases (10%) manifested moderate
degree of akathisia with parkinsonian rigidity, akathisia with dystonia and hand tremor respecti
vely that required concomitant medication of anti parkinsonian agents. The other cases could be
easily managed by dosage reduction of the next shot. Drop-out rate was only 10 percent (3cases).
According to the author’s experience, high dosage regimen seems to be troublesome both for the
patient and for the physician due to high frequency of side effects especially extrapyramidal symptoms,
even in the case of converting oral medication to fluphenazine decanoate. Initial very low dosage
with gradual increase up to lcc of the depot could be recommanded as a safe dosage regimen even
for the maintenance therapy.
목차
서 론
對象 및 方法
結 果
考 察
結論 및 要約
References
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