양극성 장애의 조기발병군과 후기발병군에 대한 비교 연구

• 영문명: A Comparative Study on Early-and Late-onset Bipolar Disorder
• 발행기관: 대한신경정신의학회
• 저자명: 한성희
• 간행물 정보: 『신경정신의학』제22권 제3호, 391~401쪽, 전체 11쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1983.08.31

영문 초록

This study was to investigate the clinical difference between early and late onset bipolar illness and was also intended to clarify the biologic basis of affective disorder. Selected for this study were 107 subjects who were diagnosed as the bipolar disorder at the Neuropsychiatric department of Korea University Hospital during the period from January, 1980 to January 1982. A total of 107 subjects of bipolar disorder were divided into early and late onset groups； age 30 years was the dividing point and 71 of them were in early onset group and 36 were in late onset group. The mean age at the onset of illness of early onset group was 19. 8 years old, and that of late onset group was 37.1 years old. The numbers of the female were much greater in the early onset group than the late one. Cyclothymic personality was the most frequent premorbid personality in both groups. Majority of both groups came from socioeconomically upper or middle class and had higher academic achievement. The effect of psychosocial stressors as a precipitating factor was significantly greater in the lateonset group than the early one. Mode of initial attack was more frequently in the form of depression than mania in both groups. Duration of hospitalization was significantly longer in the early onset group than the late one. Delusion and hallucination occurred more frequently in the early onset group than in the late onset group, and the frequency of suicidal attempts was significantly higher in the early onset group. In the frequency of parental loss by death, divorce or separation before the age of 13 years old, no significant difference was found between these two groups. Developmental abnormalities in childhood were significantly greater in the early onset group than the late onset group. In the family history, the first-degree relatives of early onset group had a higher morbidity risk for affective disorder, alcoholism and antisocial personality than the late onset probands

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