酒精과 神經傳達物質-文獻 考察

• 영문명: Alcohol and Neurotransmitters
• 발행기관: 대한신경정신의학회
• 저자명: 田珍淑 張換
• 간행물 정보: 『신경정신의학』제23권 제3호, 215~225쪽, 전체 11쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1984.08.31

영문 초록

Alcohol is capable of producing m any biochem ical changes in central nervous system . T heses changes are composed of direct prim ary effect and second ary hom eostatic response. In th is regard, acute and chronic adm inistration seem s to be a biological continuum . 1. T h e prim ary effect of acute alcohol adm inistration is initiated w ith nonspecific biophysical mechanism ra th e r th an biom em brane, and produces generalized depression of neuronal function. 2. Chronic alcohol adm inistration produces to lerance and physical dependence due to physical adaptation to th e changes of m em brane flu id ity caused by alteration of lipid com position in biological m em brane. Upon with drawal, central nervous system depression is replaced b y compensatory neuronal hyperexcitability. 3. Since 1970, investigators have been try ing to understand the role of alcohol on neurotransm itters. A lthough controversial, it seems that catecholam inergic and gam m a-am inobutyric acidergic system s are significantly involved. But, the relation with other neurotransm itters such as serotonin, acetylcholine, and peptides which have been attracting much in terest since 1980, is not clarified.

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