Alzheimer型 痴呆의 神經化學的 側面

• 영문명: Neurochemical Aspects of Dementia of the Alzheimer Type
• 발행기관: 대한신경정신의학회
• 저자명: 田珍淑 張焕
• 간행물 정보: 『신경정신의학』제24권 제2호, 175~185쪽, 전체 11쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1985.05.31

영문 초록

The dementia of the Alzheimer type has been paying attention with increasing interest in the mechanism of aging. But, unfortunately they cannot clarified whether it is qualitatively or quant itatively facilitated physiological aging or pathologically specific entity. The study on the dementia of the Alzheimer type is in the infantile stage with a few decades, history. The biochemical study started with acetylcholine and its related enzymes at the beginning, but extended to the other neurotransmitters such as noradrenaline, dopamine, serotonin, Taminobutyric acid as time went on. Recently, the investigators began to pay attention to neuropeptides such as vasopressin; its related hypophyseal hormones; that is, ACTH, B-LPH, MSH, endorphin, and enkephalin; somatostatin and oxytocin. Furthermore, the second messenger, cyclic nucleotides was suggested to be related. But, till now, the pathogenesis and the neurobiological mechanisms underlying the dementia of the Alzheimer type is not clarified.

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