Lorazepam 과 Diphenhydramine 의 추체외로증후군에 대한 효과비교

• 영문명: Comparison of the Effects between Lorazepam and Diphenhydramine for Extrapyramidal Symptoms
• 발행기관: 대한신경정신의학회
• 저자명: 서미라 최보문 백인호
• 간행물 정보: 『신경정신의학』제25권 제1호, 21~26쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1986.02.28

영문 초록

In this study, a comparative evaluation on clinical efficacy between intravenous lorazepam and diphenhydramine for extrapyramidal symptoms occurring on neuroleptic therapy was made. Subjects were consisted of 42 cases in cluding 8 males and 34 females. They were under double - blind procedure, given single injections o f 4 miligrams of lorazepam ( 21 cases) and 50 miligrams of diphenhydramine ( 21 cases) seperately. The effects were evaluated by Extrapyramidal Symptoms ( EPS ) Rating Scale for extrapyramidal Symptoms as well as by the Brief Psychiatric Rating Scale ( BPRS ) for psychotic symptoms and signs. The results were as follows : 1) Most of extrapyramidal symptoms induding parkinsonian symptoms, akathisia and dystonia were noted to be significantly improved 60 minutes after injection on EPS Rating Scale scores. 2) BPRS evaluation 60 minutes after injection resulted in significant reduction of the total mean scores in both groups, although no significant difference can be made in terms of efficacy between the group when the two groups were compared. 3) Clinically it can be suggested that the seda-tive effect of diphenhydramine was less than that of lorazepam. The above mentioned results suggest that lorazepam and diphenhydramine may well be the drugs of choice for the treatment of extrapyramidal symptoms occurring on the neuroleptic therapy.

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