만성정신분열병 환자에서 항정신병 약물과 병합한 Lithium의 임상적 효과

• 영문명: The Clinical Effects of Lithium Combined w ith Antipsychotics in the Chronic Schizophrenics
• 발행기관: 대한신경정신의학회
• 저자명: 이정국 서광윤
• 간행물 정보: 『신경정신의학』제27권 제2호, 263~276쪽, 전체 14쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1988.03.31

영문 초록

The authors studied the clinical effects of Lithium combined with antipsychotics in 24 subjects who were diagnosed as chronic schizophrenia according to DSM-III criteria ; they had not responded well to 2 or more classes of antipsychotics. And they have been maintained on the same dose for more than 2 weeks prior to this study. This study was conducted by placebo-controlled double-blind cross-over design, and BPRS (Brief Psychiatric Rating Scale), HDS (Hamilton Depression Scale), and MAS(Mania Scale) were used as rating scales. The results were as follows ; 1) Four of the 24 subjects were regarded as responders. Two of these four showed significant changes both on BPRS and HDS. The other two showed singificant changes in 3 comparisons out of 4 per each subject. In one comparison, the two-tailed P-values of both subjects were 0.0679，which almost reached significant level. 2) Discriminant analysis was done with the present age, age at onset, duration of illness and the baseline scores of BPRS of the responders and the non-responders. Only the combination of 7 items in BPRS was found to be significant(p

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