불안과 불안장애의 신경생물학

• 영문명: The Neurobiology of Anxiety and Anxiety Disorder
• 발행기관: 대한신경정신의학회
• 저자명: 김용식
• 간행물 정보: 『신경정신의학』제27권 제2호, 249~262쪽, 전체 14쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1988.03.31

영문 초록

The goal of this paper is to examine the neurobiological hypotheses of anxiety and anxiety disorders that are currently under investigation. The hypotheses are the involvement of adrenergic system and the role of locus coeruleus in animal behavior and human anxiety, the significance of lactate infusion in inducing panic attack, the association between mitral valve prolapse and panic，anxiety and the benzodiazepine/GABA receptor complex and other theories. Although the present knowledge is scant and controversial, the material reviewed in this paper strongly supports the biochemical and physiological basis of anxiety and anxiety disorders. Howerver， much more work is required to provide a reliable and reproducible neurobiological model of anxiety and anxiety disorders, for example, the detailed mechanism of lactate infusion in inducing panic attack, indentification of an endogenous ligand that interact with endogenous ligand of benzodiazepine receptor, the development of more sophisticated tools, etc.

목차

서 론

연구 방법

Adrenergic 모형

Lactate 모형

승모판탈줄(Mitral Valve Prolapse)모형

BZ /GABA 모형

기타 모형

결 론

REFERENCES