학술논문
Cytotoxic and growth inhibitory effects of live, inactivated, and cell-free supernatant components of Lactobacillus probiotics on human colorectal adenocarcinoma cell line (HT-29)
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- 영문명
- 발행기관
- 한국예방수의학회
- 저자명
- Said Abdi Salad Tran Xuan Ngoc Huy Trang Thi Nguyen Ched Nicole Turbela Aguilar Chaerim Park Hee Chol Kang Il-Hwan Kim Suk Kim
- 간행물 정보
- 『Journal of Preventive Veterinary Medicine』Vol.48, No.4, 270~273쪽, 전체 4쪽
- 주제분류
- 의약학 > 기타의약학
- 파일형태
- 발행일자
- 2024.12.31
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국문 초록
Probiotics have been evaluated as therapeutic agents for cancer treatment in an increasing number of studies. This study investigated the inhibitory and cytotoxic effects of specific Lactobacillus strains on a human colorectal adenocarcinoma cell line (HT-29). The strains assessed were Limosilactobacillus (L.) reuteri VA 102, Ligilactobacillus (L.) animalis VA 105, and Limosilactobacillus (L.) reuteri KCTC 3594 (ATCC 23272). The viability of HT-29 cells was evaluated using the MTT assay. The findings revealed that cell-free supernatants (CFS) exhibited significant anticancer effects. Heat-inactivated L. reuteri VA 105 and L. reuteri KCTC 3594 induced a pronounced reduction in cell viability. Furthermore, live cultures of L. reuteri VA 105 and L. reuteri VA 102 also showed reduced cell viability compared to the control group. These results suggest that CFS and heat-inactivated cells may be more suitable for therapeutic applications than live bacteria owing to their improved safety profiles and reduced potential for adverse effects. Our findings also emphasize the potential anticancer benefits of these LAB strains.
영문 초록
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
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- Journal of Preventive Veterinary Medicine Vol.48, No.4 Contents
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