N-13 암모니아 주사액 제조 시 멸균필터의 흡착율 차이에 관한 비교 평가

• 영문명: Studies on sterile filters in the preparation of N-13 ammonia injection
• 발행기관: 대한핵의학기술학회
• 저자명: 오창범(Chang Bum Oh) 김시활(Si Hwal Kim) 차민정(Min Jung Cha) 신진(Jin Shin) 지용기(Yong Gi Ji) 최성욱(Sung Ook Choi)
• 간행물 정보: 『핵의학기술』Vol.23 No.1, 64~68쪽, 전체 5쪽
• 주제분류: 의약학 > 방사선과학
• 파일형태: PDF
• 발행일자: 2019.04.30

영문 초록

Purpose In the preparation process for N-13 Ammonia injections, there were radioactive medicines adsorbed on filters remarkably. Hereby, we have compared the adsorption rate and quality test on Millex GS filter and Satorious Minisart filter, both representatively hydrophilic sterilizing filters, also evaluated which filter is more accommodative for N-13 Ammonia injection. Materials and Methods The filters used for sterilization of N-13 Ammonia injections were Millex GS filter(0.22 μm) mand Satorious Minisart filter (0.2 μm), which are generally used to strain aqueous solutions. After the N-13 Ammonia passes through each sterilization filter, the adsorption rate of the filter (n=10) is determined by measuring not only the radioactivity through the filter also the amount of radioactivity remaining in it using a Dose Calibrator. The N-13 Ammonia injections after each filter is tested by the quality control test to conform to the Samsung Medical Center standard. Results The ratio of radioactivity passed through Millex GS indicated 29.0 ± 17.6%. Satorious Minisart filters output was 80.9 ± 3.2%, respectively. Each ratio of radioactivity adsorbed on the sterile filter was 71.0 ± 17.6% for Millex GS and 19.1 ± 3.2% for the Satorious Minisart filters, respectively. Furthermore, on the ratio of filtered radioactivity, Using Satorious Minisart filter showed about 2.8 times higher than using Millex GS filter. The quality testing of N-13 Ammonia injections through each filter met the Samsung Medical Center standard. Conclusion The Millex GS filter is composed of cellulose acetate and cellulose nitrate, whereas the Satorious Minisart filter if composed only of cellulose acetate. Therefore, the presence of cellulose nitrate in the membrane seems to have made differences. Therefore, the use of Satorious Minisart filter in the preparation of N-13 Ammonia injection solution minimized the loss of radioactive medicines due to filter adsorption, thereby improving the synthesis yield.

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실험재료 및 방법

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키워드

N-13 ammonia sterile filter CAD,